Table 4.
Characteristics of patients according to the scales of P-WMH and D-WMH.
| Variables | P-WMH | D-WMH | ||||
|---|---|---|---|---|---|---|
| None–mild | Moderate–severe | P value | None–mild | Moderate–severe | P value | |
| n = 304 | n = 291 | n = 348 | n = 247 | |||
| Age (years) | 55.0 (49.0–63.0) | 67.0 (60.0–72.0) | <0.001 | 57.0 (50.0–64.0) | 67.0 (59.0–72.0) | <0.001 |
| Sex (male, N, %) | 87 (28.6%) | 105 (36.1%) | 0.052 | 244 (70.1%) | 159 (64.4%) | 0.140 |
| HBP (N, %) | 191 (62.8%) | 233 (80.1%) | <0.001 | 223 (64.1%) | 201 (81.4%) | <0.001 |
| DM (N, %) | 73 (24.0%) | 99 (34.0%) | 0.007 | 98 (28.2%) | 74 (30.0%) | 0.633 |
| Hyperlipidemia (N, %) | 88 (28.9%) | 85 (29.2%) | 0.944 | 95 (27.3%) | 78 (31.6%) | 0.257 |
| CAD (N, %) | 37 (12.2%) | 65 (22.3%) | 0.001 | 44 (12.6%) | 58 (23.5%) | <0.001 |
| Smoking (N, %) | 153 (50.3%) | 131 (45.0%) | 0.195 | 169 (48.6%) | 115 (46.6%) | 0.630 |
| Drinking (N, %) | 108 (35.5%) | 105 (36.1%) | 0.888 | 124 (35.6%) | 89 (36.0%) | 0.920 |
| SBP (mmHg) | 142.0 (127.0–155.0) | 143.0 (130.0–158.5) | 0.096 | 141.0 (129.0–154.0) | 145.0 (130.0–161.0) | 0.017 |
| DBP (mmHg) | 83.0 (74.0–94.0) | 82.0 (73.0–90.0) | 0.190 | 83.0 (74.0–92.0) | 82.0 (73.0–91.5) | 0.613 |
| BMI | 23.6 (22.0–25.2) | 23.0 (20.8–25.8) | 0.279 | 23.3 (21.9–25.6) | 23.4 (20.9–25.7) | 0.720 |
| PAGln (μmmol/L) | 1.8 (1.0–2.7) | 2.4 (1.5–3.8) | <0.001 | 1.9 (1.1–2.9) | 2.4 (1.5–3.8) | <0.001 |
| White blood cell count ( ×109 /L) | 6.7 (5.4–8.2) | 6.7 (5.6–8.0) | 0.884 | 6.7 (5.5–8.1) | 6.7 (5.5–8.0) | 0.904 |
| Platelet ( ×109/L) | 207.0 (167.8–249.0) | 199.0 (163.0–239.5) | 0.113 | 207.0 (167.8–249.0) | 199.0 (163.0–239.5) | 0.113 |
| BUN (mmol/L) | 4.9 (3.9–5.9) | 5.2 (4.2–6.4) | 0.009 | 5.0 (3.9–6.0) | 5.1 (4.2–6.3) | 0.033 |
| eGFR (ml/min/1.73 m2) | 88.5 (74.0–98.7) | 77.7 (64.2–89.1) | <0.001 | 88.4 (74.6–98.2) | 76.7 (62.2–88.2) | <0.001 |
| Uric acid (μmol/L) | 318.6 (273.1–385.7) | 328.1 (267.1–385.8) | 0.799 | 315.0 (272.3–379.1) | 339.8 (271.2–393.2) | 0.204 |
| TC (mmol/L) | 4.2 (3.4–5.2) | 4.2 (3.4–4.9) | 0.143 | 4.2 (3.4–5.2) | 4.3 (3.5–5.0) | 0.415 |
| TG (mmol/L) | 1.6 (1.2–2.2) | 1.5 (1.0–2.2) | 0.045 | 1.6 (1.1–2.2) | 1.5 (1.0–2.3) | 0.154 |
| HDL (mmol/L) | 1.0 (0.8–1.2) | 1.0 (0.9–1.2) | 0.669 | 1.0 (0.8–1.1) | 1.0 (0.9–1.2) | 0.004 |
| LDL (mmol/L) | 2.6 (2.1–3.4) | 2.6 (2.0–3.1) | 0.123 | 2.6 (2.0–3.3) | 2.6 (2.1–3.2) | 0.565 |
| Fasting blood–glucose (mmol/L) | 5.6 (4.9–6.9) | 5.7 (5.0–7.7) | 0.213 | 5.6 (5.0–7.4) | 5.7 (5.0–7.3) | 0.882 |
| HbA1c (%) | 5.8 (5.4–6.5) | 6.0 (5.5–7.1) | 0.314 | 5.8 (5.4–7.2) | 5.9 (5.6–6.8) | 0.647 |
| Homocysteine (μmol/L) | 12.7 (10.8–15.1) | 14.0 (11.4–17.8) | <0.001 | 12.8 (10.8–15.5) | 14.0 (11.6–18.3) | 0.001 |
P-WMH, periventricular white matter hyperintensity; D-WMH, deep white matter hyperintensity; HBP, hypertension; DM, diabetes mellitus; CAD, coronary artery disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; PAGln, phenylacetylglutamine; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; TC, total cholesterol; TG, triglycerides; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycosylated hemoglobin A1c.