Skip to main content
. 2021 Jul 30;13:675158. doi: 10.3389/fnagi.2021.675158

Table 5.

Logistic regression analyses of the association between PAGln levels and P-WMH and D-WMH.

P-WMH D-WMH
P value OR 95% CI for OR P value OR 95% CI for OR
Lower Upper Lower Upper
Unadjusted model Unadjusted model
PAGln levels PAGln levels
First quartile Reference First quartile Reference
Second quartile 0.003 2.021 1.263 3.235 Second quartile 0.022 1.748 1.083 2.823
Third quartile 0.024 1.719 1.073 2.755 Third quartile 0.177 1.396 0.860 2.266
Fourth quartile <0.001 4.816 2.9491 7.867 Fourth quartile <0.001 3.220 1.993 5.201
Adjusted model a Adjusted model a
PAGln levels PAGln levels
First quartile Reference First quartile Reference
Second quartile 0.062 1.637 0.976 2.747 Second quartile 0.171 1.428 0.858 2.379
Third quartile 0.983 0.994 0.585 1.689 Third quartile 0.629 0.878 0.518 1.488
Fourth quartile 0.004 2.247 1.297 3.890 Fourth quartile 0.065 1.648 0.970 2.799
Age (years) <0.001 1.088 1.067 1.110 Age (years) <0.001 1.068 1.049 1.088
Sex (male) 0.494 0.872 0.588 1.291 Sex (male) 0.684 0.924 0.633 1.349
Adjusted model b Adjusted model b
PAGln levels PAGln levels
First quartile Reference First quartile Reference
Second quartile 0.286 1.383 0.762 2.511 Second quartile 0.475 1.243 0.685 2.255
Third quartile 0.859 1.056 0.577 1.933 Third quartile 0.730 0.899 0.489 1.651
Fourth quartile 0.014 2.227 1.174 4.226 Fourth quartile 0.057 1.819 0.981 3.372
Age (years) <0.001 1.077 1.051 1.103 Age (years) <0.001 1.054 1.031 1.078
Sex (male vs. female) 0.377 0.796 0.480 1.321 Sex (male vs. female) 0.750 1.082 0.665 1.761
HBP 0.377 1.255 0.759 2.075 HBP 0.076 1.609 0.951 2.723
DM 0.414 1.215 0.761 1.939 CAD 0.724 1.103 0.640 1.901
CAD 0.974 0.990 0.561 1.749 SBP >142 mmHg 0.692 1.092 0.708 1.684
BUN >5.01 mmol/L 0.899 0.972 0.623 1.515 BUN >5.01 mmol/L 0.307 0.795 0.512 1.235
eGFR ≤ 83.85mL/min/1.73 m2 0.305 1.277 0.800 2.038 eGFR ≤ 83.85mL/min/1.73 m2 0.051 1.584 0.998 2.513
TG >1.52 mmol/L 0.154 0.733 0.479 1.123 HDL >1.00 mmol/L 0.006 1.847 1.196 2.853
Homocysteine >13.28 μmol/L 0.119 1.437 0.910 2.268 Homocysteine >13.28 μmol/L 0.260 1.303 0.822 2.067
a

Adjusted modela: adjusted for age and sex.

b

P-WMH adjusted modelb: adjusted for age, sex, HBP, DM, CAD, BUN, eGFR, TG, and homocysteine levels.

D-WMH adjusted modelb: adjusted for age, sex, HBP, CAD, SBP, BUN, eGFR, HDL, and homocysteine levels.

WMH, white matter hyperintensity; P-WMH, periventricular white matter hyperintensity; D-WMH, deep white matter hyperintensity; OR, odds ratio; CI, confidence interval; PAGln, phenylacetylglutamine; HBP, hypertension; DM, diabetes mellitus; CAD, coronary artery disease; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; TG, triglycerides; HDL, high-density lipoprotein; SBP, systolic blood pressure.