FIGURE 1.

(A–H) Effect of age and apigenin diet on Barnes Maze Acquisition in WT and GFAP-IL6 mice. Primary Acquisition latency (s) is presented for standard diet-fed mice in (A) and apigenin-fed mice in (B), and Average Path length (m) is shown for standard diet-fed mice in (C) and apigenin-fed mice in (D). Average Errors (n) is displayed for standard diet-fed mice in (E) and apigenin-fed mice in (F), while average speed (m/s) is presented for standard diet-fed mice in (G) and apigenin-fed mice in (H). Data analyzed with four-way ANOVA, followed by Bonferroni post hoc tests. Post hoc effects of “genotype” within the same age and treatment group are indicated by stars (*p < 0.05). Data presented as means ± SEM.