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. 2021 Jul 30;15:699329. doi: 10.3389/fnins.2021.699329

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Copyright © 2021 Chesworth, Gamage, Ullah, Sonego, Millington, Fernandez, Liang, Karl, Münch, Niedermayer and Gyengesi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Effect of age and apigenin diet on Barnes Maze Probe Test Performance in WT and GFAP-IL6 mice. Entries (n) into the escape hole is presented for (A) control and (B) apigenin-fed mice. Distance traveled (m) at Probe for all groups is presented in (C). A main effect of genotype and age in (C) indicates reduced distance traveled in GFAP-IL6 mice compared to WT controls, and reduced distance traveled in 22-month-old mice compared to 6-month-old mice. Data analyzed with three- and four-way ANOVA, followed by Bonferroni post hoc tests. Post hoc effects of “location” within the same age and treatment group are indicated by hash symbols (#p < 0.05, ###p < 0.001). Data presented as means ± SEM.