Fig. 5.

Treatment of Tg2576 AD model mice with memantine prevents CCR in vivo. (A) Tg2576 and wild type mice were provided ad libitum access to drinking water with or without memantine from the time of weaning at 3 weeks until 2 months of age. Brain sections from each condition were stained by triple immunofluorescence for the neuron-specific protein, βIII-tubulin, cyclin D1, and NeuN to identify CCR-positive neurons. (B) Quantification of the immunofluorescence results and statistical analysis by one-way ANOVA. Error bars indicate S.E.M. Abbreviations: AD, Alzheimer’s disease; ANOVA, analysis of variance; CCR, cell cycle reentry.