TABLE 3.

Association of microvascular pathology with LATE‐NC (Odds ratios and 95% confidence intervals, p‐values)

Predictors	Model 1	Model 2	Model 3	Model 4	Model 5	Model 6*
Age at death	1.06 (1.03, 1.08), p < 0.001	1.06 (1.04, 1.09), p < 0.001	1.06 (1.04, 1.09), p < 0.001	1.06 (1.03, 1.08), p < 0.001	1.06 (1.04, 1.09), p < 0.001	1.06 (1.04, 1.09), p < 0.001
Male sex	0.83 (0.62, 1.12), p = 0.241	0.85 (0.63, 1.14), p = 0.280	0.86 (0.64, 1.16), p = 0.347	0.84 (0.62, 1.13), p = 0.268	0.85 (0.63, 1.15), p = 0.309	0.92 (0.68, 1.25), p = 0.627
Education	0.98 (0.95, 1.02), p = 0.539	0.98 (0.95, 1.02), p = 0.535	0.98 (0.95, 1.02), p = 0.592	0.98 (0.95, 1.02), p = 0.555	0.98 (0.94, 1.02), p = 0.491	0.99 (0.95, 1.03), p = 0.671
PWS arteriolosclerosis	1.11 (1.01, 1.24), p = 0.035					1.12 (1.01, 1.25), p = 0.038
AWS arteriolosclerosis		1.01 (0.90, 1.12), p = 0.882
BG arteriolosclerosis			0.99 (0.86, 1.13), p = 0.924
CAA				1.26 (1.09, 1.45), p < 0.001
Microinfarcts					0.86 (0.65, 1.14), p = 0.308
Global AD score						1.88 (1.50, 2.35), p < 0.001

Abbreviations: PWS, posterior watershed; AWS, anterior watershed; BG, basal ganglia; CAA, cerebral amyloid angiopathy.

^*Additionally, adjusted for Lewy body disease, gross infarcts, and atherosclerosis.