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. 2021 Jul 30;12:700152. doi: 10.3389/fimmu.2021.700152

Figure 3.

Figure 3

Pyroptotic MAIT cells increased in patients with COVID-19. (A) Box plots of the expression levels of genes associated with four GO biological process in MAIT cells derived from the HD (n = 5), moderate (n = 7), severe (n = 4), and conv (n = 6) samples. Conditions are displayed in different colors. Horizontal lines represent median values, with whiskers extending to the farthest data point within a maximum of 1.5 × the interquartile range. (B) The expression level of the CASP1 gene in participants from four conditions. A dot represents a single sample. Samples and their corresponding conditions are displayed in different colors. (C) Comparisons of FLICA caspase-1 in peripheral CD4+ T, CD8+ T and MAIT cells from healthy donors and patients with COVID-19. Statistical analysis was performed using SPSS software version 22 (IBMCorp., Armonk, New York, USA). For comparison, the Mann–Whitney U test was used for comparisons between healthy donors and patients with COVID-19. A paired Student’s t-test was adopted for the analysis of CD4+ T, CD8+ T and MAIT cells in the same group. p values < 0.05 indicated a significant difference. HD, healthy donor.