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. 2021 Jul 30;12:674532. doi: 10.3389/fimmu.2021.674532

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Copyright © 2021 Fernandes, Patil, Meriaux, Theresine, Muller, Leenen, Elwenspoek, Zimmer and Turner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early life separation induces functional changes in rat and human NK cells. (A) Maturation state of rat NK cells defined by CD27 and CD11b markers. Cells were gated from CD161a+/Nkp46+ NK cells; (B) Cytotoxic response of rat NK cells to YAC-1 cells; (C) Cytotoxic response of NK cells from institutionalized individuals to K562 cells. Data is presented as mean ± SEM of 6 animals per group or 14 donors per group. Statistics: Two-way ANOVA; *p < 0.05; **p < 0.01; ***p < 0.001. Representative Figures for flow data are included in the Supplementary Material.