TABLE 1.

A comparision of JWH133 and main phytocannabinoids in terms of binding type and binding affinity.

Cannabinoids	Binding type/CB	CB1 Ki value (nM)	CB2 Ki value (nM)	References
	Full agonist/CB2	677	3.4	Pertwee et al. (2010)
	Full agonist/CB2	NA	155	Gertsch et al. (2008)
	Partial agonist/CB1,CB2	5 to 80	1.7 to 75	Turner et al. (2017)
	Antagonist/inverse agonist, negative allosteric modulator/CB1	73 to >10,000	370 to >10,000	Turner et al. (2017)
	Partial agonist/CB2
	Agonist/CB1,CB2	1.2	6.2	Citti et al. (2019)