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. 2021 Aug 10;10:e64644. doi: 10.7554/eLife.64644

Figure 1. Schematic representation of signaling pathways activating ERK.

Figure 1.

(A) Five pathways are included in the model: calcium activation of (1) RasGRF followed by RasGTP production or (2) CaMKII phosphorylation of SynGap followed by increasing RasGTP and Rap1GTP lifetime; cAMP activation of (3) Epac or (4) PKA phosphorylation of Src family kinase, leading to Rap1GTP production; Gi subtype of GTP binding protein (Giβγ) (5) recruits Src family kinase followed by activation of RasGTP. (B) Four effects of CaMKII on SynGap were evaluated. KCK: No autophosphorylation of CaMKII, KSyn1: No pCaMKII binding to SynGap, KSyn2: SynGap binds to pCaMKII, but cannot be phosphorylated, KSyn3: SynGap phosphorylated, but not dispersed to the dendrite. (C) LTP protocols: four trains of 100 Hz (each 1 s duration) spaced by different intertrial intervals: 3, 20, 40, 80, and 300 s.

Figure 1—source data 1. Reactions and rate constants involved in signaling pathway leading to Ras and Rap1 activation.
Figure 1—source data 2. Reactions and rate constants involved in signaling pathway of SynGap.
Figure 1—source data 3. Reactions and rate constants involved in core ERK signaling pathway.
Figure 1—source data 4. Reactions and rate constants involved in signaling pathways from calcium to CaMKII.
Figure 1—source data 5. Reactions and rate constants involved in signaling pathways leading from cAMP to PKA.
Figure 1—source data 6. Total concentrations of molecule species.