. 2021 Aug 10;10:e64644. doi: 10.7554/eLife.64644

Table 3. Knockout experiment.

Rate constant names are shown in Figure 1A,B. Block lists the rate constant whose value is set to zero.

Input	Block	Effect/molecular dependence
Calcium 2000 nM for 1 s	K_CK	CaMKII is activated but cannot autophosphorylate itself, thus RasGRF is the only contributor
	K_Syn1	pCaMKII is unable to bind to SynGap
	K_Syn2	pCaMKII binds to SynGap but is unable to phosphorylate SynGap
	K_Syn3	SynGap is phosphorylated but is unable to disperse to the dendrite
cAMP 500 nM for 30 s	K_Epac	Epac binds cAMP but cannot activate Rap1GDP, thus PKA is the only contributor
cAMP 500 nM for 30 s	K_PKA	Final step of PKA pathway activation of Rap1GDP is blocked, thus Epac is the only contributor