Table 7. Random forest analysis.
One hundred random perturbations of all molecule concentrations (between +10% and −10%) were simulated. Features are ranked from most important to least important in predicting the temporal sensitivity. The sum of features’ importance equals 1.
| Molecules abbreviation | Weights | Molecules full name |
|---|---|---|
| RasGRF | 0.084 | Ras guanine nucleotide–releasing factor |
| Sos | 0.074 | Son of sevenless |
| Cam | 0.068 | Calmodulin |
| MEK | 0.050 | Mitogen-activated protein kinase kinase |
| PDE2 | 0.050 | Phosphodiesterase 2 |
| pmca | 0.048 | Plasma membrane calcium pump |
| Epac | 0.046 | Exchange protein directly activated by cAMP |
| Calbin | 0.046 | Calbindin |
| CRKC3G | 0.044 | v-CRK Proto-Oncogene/Rap guanine nucleotide exchange factor 1 |
| rasGap | 0.043 | Ras GTPase-activating protein |
| SynGap | 0.042 | Synaptic rasGap |
| PP1 | 0.038 | Protein phosphatase 1 |
| Shc | 0.035 | Src homology collagen-like |
| Grb2 | 0.034 | Growth factor receptor-bound protein 2 |
| PP2A | 0.033 | Protein phosphatase 2 |
| MKP1 | 0.033 | Mitogen-activated protein kinase phosphatase 1 |
| Ng | 0.033 | Neurogranin |
| Src | 0.032 | Non-receptor tyrosine kinase |
| Cbl | 0.030 | Casitas B-lineage lymphoma |
| ERK | 0.027 | Mitogen-activated protein kinase |
| PDE4 | 0.025 | Phosphodiesterase 4 |
| PKA | 0.025 | Protein kinase A |
| NCX | 0.022 | Sodium calcium exchanger |