Figure 1. Flow chart of the integrative analysis of DNA methylation and gene expression profiles for the identification of MIND and its assessment in the lung cancer validation cohorts.

The boxes and their corresponding notes indicate the analysis, criteria, and data set used at each step. MIND, DNA methylation index for NF/CAF discrimination; RMA, robust multiarray average; KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, gene set enrichment analysis.