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. 2021 Aug 16;131(16):e144016. doi: 10.1172/JCI144016

Figure 4. Global knockout of 14-3-3ε renders B6 mice highly susceptible to CIA.

Figure 4

(A) Clinical arthritis scores and incidence of arthritis in the indicated mice with CIA. Data are mean ± SEM; n = 14 mice per group; significant difference was analyzed by 1-way ANOVA with Bonferroni’s post hoc test; *P < 0.05 or **P < 0.01. (B and C) Representative images of H&E staining, and quantification of histomorphometric analysis of synovial inflammation of ankle joints (n = 8 mice per group). Scale bar: 100 μM. (D–I) The percentage of macrophages (D), Edu-labeled macrophages in total macrophages (E), iNOS mean fluorescence intensity (MFI) of macrophages (F), percentage of CD206+ cells in CD11b+F4/80+ cells (G), percentage of neutrophils (H), and percentage of EdU-labeled neutrophils in total neutrophils (I) in the joints of indicated mice with CIA (n = 6 mice for each group) were determined by flow cytometry. In C–I, data are mean ± SD; significant difference was analyzed by 1-way ANOVA with Bonferroni’s post hoc test.