Figure 5. Resistance of vaginal biopsies from VRC01-infused participants to ex vivo HIV-1_Bal26 challenge.

(A) HIV-1 infection kinetics for vaginal explants from VRC01-infused participants challenged with HIV-1_Bal26. Each curve corresponds to the infection readout of a single biopsy throughout its 3-week culture (n = 5). Graphs are arranged by infusion dose (left, 10 mg/kg; right, 30 mg/kg) and collection time postinfusion. (B) Total HIV-1 replication in individual explants challenged with HIV-1_Bal26 from VRC01-infused (n = 5) and uninfused control (n = 8) participants summarized by scaled log RLU AUC. Unique symbols are used to denote explants from different donors. Statistical significance was assessed by Mann-Whitney tests.