Figure 6. Correlation analysis of systemic and mucosal levels of VRC01 between compartments and in relation to ex vivo HIV-1 infection of rectal explants.
(A and B) Relationships between IgG-normalized concentrations in sera, tissue homogenates, and secretions from male (n = 7) (A) and female (n = 5) (B) participants. (C) Relationships between total ex vivo HIV-1Bal26 replication and IgG-normalized VRC01 levels in male participants (n = 7). Black-bordered symbols indicate participants in whose rectal biopsies ex vivo HIV-1 replication was detected. Correlations were determined by Spearman’s rank coefficients.