Table 5.
Association between lung cancer risk and exposure to organic dust, stratified by histology
| Exposure to organic dust | Controls | Squamous and small cell carcinoma | Adenocarcinoma | |||
|---|---|---|---|---|---|---|
| N | N | OR* (95% CI) | N | OR* (95% CI) | ||
| Total population | Never | 8,940 | 3,520 | 1.00 (ref) | 1,816 | 1.00 (ref) |
| 1st Quartile | 1,770 | 868 | 1.10 (0.99–1.22) | 382 | 0.92 (0.81–1.05) | |
| 2nd Quartile | 1,914 | 1,115 | 1.25 (1.13–1.38) | 455 | 1.00 (0.88–1.13) | |
| 3rd Quartile | 1,804 | 996 | 1.23 (1.11–1.36) | 392 | 1.01 (0.88–1.15) | |
| 4th Quartile | 1,845 | 1,146 | 1.39 (1.26–1.54) | 347 | 0.97 (0.84–1.11) | |
| Test for trend, p-value† | <.001 | 0.950 | ||||
| Never smokers | Never | 2,971 | 144 | 1.00 (ref) | 251 | 1.00 (ref) |
| 1st Quartile | 498 | 36 | 1.17 (0.78–1.76) | 44 | 0.76 (0.54–1.09) | |
| 2nd Quartile | 576 | 41 | 1.18 (0.80–1.75) | 54 | 0.84 (0.60–1.16) | |
| 3rd Quartile | 540 | 47 | 1.50 (1.04–2.16) | 57 | 0.95 (0.69–1.31) | |
| 4th Quartile | 592 | 44 | 1.16 (0.78–1.75) | 51 | 0.87 (0.61–1.21) | |
| Test for trend, p-value† | 0.106 | 0.819 | ||||
*
ORs are adjusted for age, sex, study, pack-years, time-since-quitting smoking (where appropriate), and ever employment in a ‘list A job’
†
P-values for trend result from logistic regression model with exposure as continuous variable