Fig. 2.

Cytokine profiles in placebo and vaccine groups

Individual values for each subject are shown as small closed circles. Open circles with error bars represent geometric mean with 95% CI for each time point. All concentrations are presented as pg/mL after the background subtraction. Groups were compared by two-way RM-ANOVA (applied to the log10 values), followed by Bonferroni's multiple comparison test; * p < 0·05, *** p–0·001, and **** p–0·0001- indicate statistically significant differences between groups is.