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. 2021 May 26;27(8):1362–1366. doi: 10.1038/s41591-021-01387-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Pre- and post-vaccination antibody levels against SARS-CoV-2 antigenic motifs. b, PIWAS values pre- and post-vaccination against non-spike sequences of the SARS-CoV-proteome compared to patients with SARS-CoV-2 positive subjects24 (Methods). Box plots of PIWAS values of SARS-CoV-2 positive subjects are shown, where boxes denote the IQR, and the median is shown as horizontal bars. Whiskers extend to 1.5x IQR and outliers are shown as individual points (n = 230 subjects; n = 230 biologically independent samples). IQR, interquartile range; PIWAS, protein-based immunome wide association study; SERA, serum epitope repertoire analysis.