. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: Eur J Med Genet. 2021 Jun 20;64(9):104267. doi: 10.1016/j.ejmg.2021.104267

Table 4.

Geometric features with significantly different ranges between the normative population and the patients with DS in the DRC that were not selected for classification. Horizontal features (H) are normalized to the distance between the lateral canthi. Vertical features (V) are normalized to the distance between the oral commissures and the lateral canthi.

Feature	Mean: Normal	Std: Normal	Mean: Syndromic	Std: Syndromic	p-value
Distance between medial and lateral canthi (H)	0.30	0.01	0.27	0.01	<0.001
Distance between nose alas (H)	0.43	0.03	0.46	0.04	<0.001
Upper lip width (V)	0.16	0.03	0.18	0.03	<0.001
Lower lip width (V)	0.18	0.03	0.17	0.04	0.001
Angle at the alas of the nose (degrees)	54.86	5.36	57.56	6.20	0.011