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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Pregnancy Hypertens. 2021 May 14;25:39–47. doi: 10.1016/j.preghy.2021.05.002

Figure 1: Effect of TNF-α Blockade on Mean Arterial Pressure and Intrauterine Growth Restriction in Pregnant Rats.

Figure 1:

On Gestation Day (GD) 14, either the Reduced Uterine Perfusion Pressure (RUPP) procedure or a Sham procedure was performed on pregnant Sprague Dawley rats. On GD 15 and 18, vehicle or 0.4 mg/kg Etanercept (ETA) was injected i.p. in a subset of Sham and RUPP rats. On GD 19, conscious Mean Arterial Pressure (A) was measured and fetal weights, (B) placental weights (C),and fetal resorptions (D) were recorded under isoflurane anesthesia. Sham n=10; RUPP n=10; Sham+ETA n=10; RUPP+ETA n=10. All data are expressed as mean ± SEM. Statistical analyses were performed using two-way ANOVA with multiple comparisons followed by Tukey’s post-hoc test. *p<0.05 versus Sham; #p<0.05 vs RUPP.