Table 1.

Patients characteristics

Patient	Age (years)	Gender	Predisposing condition	Location	Tumour volume (cm3)	Metastasis at presentation	Osteosarcoma subtype	Residual tumor cells (%)	Histological response to chemotherapy
1	18.5	F	–	distal femur	60.7	–	osteoblastic	8	Good
2	15	M	–	distal femur	1,199.5	–	osteochondroblastic	7	Good
3	14	M	–	distal femur	405.2	–	chondroblastic	1	Good
4	12.2	M	–	proximal humerus	101.6	–	chondroblastic	2	Good
5	19.6	F	–	proximal tibia	107.3	–	osteoblastic	16	Poor
6	16.3	F	–	distal femur	123	–	osteoblastic	5	Good
7	14.4	F	–	distal femur	221.4	–	osteochondroblastic	20	Poor
8	10.5	F	–	proximal tibia	61.7	lung	osteoblastic	75	Poor
9	4.7	M	–	distal femur	98.4	lung	osteoblastic	70	Poor
10	12.7	F	–	distal femur	46.1	–	osteoblastic	13	Poor
11	8.8	M	–	distal femur	94.2	–	osteoblastic	8	Good
12	16.5	M	–	proximal tibia	147.1	lung	osteoblastic	15	Poor
13	16.4	F	–	femoral diaphysis	320.4	–	osteoblastic	1	Good
14	14.4	F	–	distal femur	179	–	osteochondroblastic	20	Poor
15	16.3	F	–	proximal tibia	227	–	osteoblastic	20	Poor
16	8.7	F	–	distal femur	368.1	bone	osteoblastic	12	Poor
17	9.5	M	–	proximal tibia	181.4	lung	osteoblastic	3	Good
18	12.7	F	–	distal femur	264	lung	osteoblastic	23	Poor
19	9.4	F	–	distal femur	437.9	bone	osteoblastic	1	Good
20	8.9	F	Li Fraumeni	distal femur	64.7	–	osteoblastic	10	Good
21	11.8	M	–	proximal tibia	405	lung	chondroblastic	25	Poor
22	7.5	M	–	femoral diaphysis	105.9	–	osteoblastic	0	Good
23	14.6	M	–	distal femur	323.7	–	osteoblastic	25	Poor
24	16.9	M	–	proximal tibia	251.5	–	osteoblastic	9	Good
25	10	F	–	proximal tibia	70.1	–	osteoblastic	7	Good
26	13.3	F	–	proximal humerus	456.8	–	osteoblastic	3	Good

High-risk factors for poor outcome include tumour size, initial metastases, poor histological response and unresectable primary tumour. Because surgical margins were negative for all patients, this feature is ommtted from the table. F female, M male