Table 2.
Associations of a-FABP with central hemodynamic indices and key cardiac structural and functional parameters.
| (Per 10 ng/mL a-FABP increment) | Uni-variate model | Multi-variate model 1 | Multi-variate model 2 | |||
|---|---|---|---|---|---|---|
| Coef. (95% CI) | p value | Coef. (95% CI) | p value | Coef. (95% CI) | p value | |
| Central and peripheral hemodynamic indices | ||||||
| CSP (mmHg) | 3.05 (1.60, 4.51) | 0.001 | 2.72 (1.23, 4.20) | < 0.001 | 2.00 (0.78, 3.21) | 0.001 |
| CDP (mmHg) | 1.45 (0.68, 2.21) | 0.01 | 1.08 (0.19, 1.97) | 0.018 | 0.57 (− 0.13, 1.28) | 0.11 |
| CPP (mmHg) | 2.35 (1.16, 3.54) | < 0.001 | 1.59 (0.73, 2.45) | < 0.001 | 1.42 (0.45, 2.39) | 0.004 |
| PPA (ratio) | 0.001 (− 0.03, 0.03) | 0.90 | 0.005 (− 0.03, 0.04) | 0.77 | 0.002 (− 0.004, 0.01) | 0.50 |
| AIx (%) | 0.85 (0.25, 1.45) | 0.006 | 0.64 (0.05, 1.24) | 0.035 | 0.37 (− 0.27, 1.01) | 0.26 |
| Cardiac structure and function | ||||||
| Left ventricular mass index (gm/m2*) | 2.23 (− 0.54, 1.80) | 0.001 | 2.07 (1.06, 3.09) | < 0.001 | 1.20 (0.14, 2.25) | 0.026 |
| TDI-e′ (average) (cm/s) | − 0.26 (− 0.37, − 0.15) | < 0.001 | − 0.17 (− 0.27, − 0.07) | 0.001 | − 0.11 (− 0.22, − 0.01) | 0.036 |
| E/TDI-e′ (average) | 0.69 (0.40, 0.97) | < 0.001 | 0.34 (0.15, 0.53) | < 0.001 | 0.20 (0.003, 0.40) | 0.046 |
| TDI-s′ (average) (cm/s) | − 0.12 (− 0.20, − 0.04) | 0.005 | − 0.07 (− 0.15, 0.01) | 0.089 | − 0.02 (− 0.11, 0.06) | 0.59 |
| GLS (%) | 0.30 (0.17, 0.44) | < 0.001 | 0.27 (0.14, 0.41) | < 0.001 | 0.18 (0.04, 0.33) | 0.013 |
*In which model body mass index was not entered. Multi-variate Model 1: Adjusted for age, gender; Multi-variate Model 2: Model 1 plus body mass index (BMI), hypertension (yes/no), diabetes mellitus (yes/no), active smoking status (yes/no), coronary artery disease (yes/no), stroke (yes/no), renal function (eGFR).
AIx, aortic augmentation index; CSP, central systolic pressure; CDP, central diastolic pressure; CPP, central pulse pressure; GLS, global LV longitudinal systolic myocardial strain; PPA, peripheral pulse pressure amplification; TDI-e′, peak myocardial diastolic relaxation velocity on tissue-based Doppler; E/TDI-e′, mitral inflow E wave divided by TDI-e′; TDI-s′, peak myocardial systolic relaxation velocity of tissue-based Doppler.