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. 2021 Aug 13;4:966. doi: 10.1038/s42003-021-02488-1

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Fluorescence in situ hybridization of Ptgs1 and COX2 in Trp53^f/f and Trp53^d/d implantation sites on day 8 of pregnancy. The embryonic trophoblasts are outlined by Cytokeratin 8 (CK8) immunostaining. M mesometrial pole; AM anti-mesometrial pole; Em embryo; SDZ secondary decidual zone; Myo myometrium; scale bar, 500 µm. B Segmented RT-qPCR results for Ptgs2, Ptgs1, Ptgds, Hpgds, in the AM and M-poles in Trp53^f/f and Trp53^d/d implantation sites on day 8 of pregnancy. C Segmented RT-qPCR results showing the expression of Ptgs2, Ptgs1, Ptgds and Hpgds, Pgdh, Ptgdr, and Ptgdr2 in the M-pole and AM-pole of the implantation sites comparing the Trp53^f/f and Trp53^d/d implantation sites. Significance is determined by a two-tailed student’s t-test, where * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001.