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. 2021 Aug 13;12:4910. doi: 10.1038/s41467-021-24879-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Original HNRNH1 and AdML pre-mRNAs and chimeric HNRNH1 pre-mRNAs are schematically shown (red color indicates AdML derived sequences). These pre-mRNAs were expressed from mini genes in HeLa cells and their splicing was assayed by RT-PCR. PAGE images and quantifications of RT-PCR are shown. Means ± SEM are given for three independent experiments and two-tailed Student t-test values were calculated (p = 0.0027 for Control siRNA vs SPF45 siRNA in HNRNPH1 intron, p = 0.9394 for Control vs SPF45 siRNA in AdML intron, p = 0.7548 for Control siRNA vs SPF45 siRNA in HNRNPH1 intron/AdML PPT25, p = 0.1961 for Control siRNA vs SPF45 siRNA in HNRNPH1 intron/AdML PPT25mt, p = 0.0011 for Control siRNA vs SPF45 siRNA in HNRNPH1 intron/AdML PPT13, p = 0.0004 for Control siRNA vs SPF45 siRNA in HNRNPH1 intron/AdML 5′mt. **P < 0.01, ***P < 0.001, ^n.s.P > 0.05. Source data of the above panels are provided as a Source Data file.