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. 2021 Aug 13;12:4910. doi: 10.1038/s41467-021-24879-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — The associated splicing factors with the domain structures and the target sequences of pre-mRNAs are represented schematically. On short intron with truncated PPT (Tr. PPT), U2AF heterodimer is replaced by SPF45 and interacts with SF3b155 (U2 snRNP component) via UHM–ULM binding to promote splicing. Since both U2AF⁶⁵ and SPF45 can bind to long introns simultaneously via five ULMs in SF3b155, the alternative model that U2AF⁶⁵ displaces SPF45 in long introns would be impossible.