Fig. 1. Mutational frequencies of known cognitive impairment disease-associated genes in AD, FTD, and entire cohorts respectively.

Mutational frequencies of all (left) and each (right) known cognitive impairment-associated genes in the different dementia cohorts. a AD cohort. b FTD cohort. c entire cohort. Variants that were classified as pathogenic or likely pathogenic according to the standards and guidelines of the ACMG. ‘Pathogenic’ means that the patients had pathogenic variants in known cognitive impairment disease-associated genes, and ‘likely pathogenic’ means that the patients had likely pathogenic variants in known cognitive impairment disease-associated genes. ACMG American College of Medical Genetics, AD Alzheimer’s disease, FTD frontotemporal dementia.