Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 13;6:69. doi: 10.1038/s41525-021-00235-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Comparison of AAO in all patients with P/LP variants of known cognitive impairment disease-associated genes and patients without P/LP variants in known cognitive impairment disease-associated genes. a AD cohort. b FTD cohort. c Entire cohort. The dashed red line refers to the mean AAO of patients with P/LP variants in the corresponding cohorts, whereas the dashed line refers to the mean AAO of patients without P/LP variants in known cognitive impairment disease-associated genes in the corresponding cohort. d Spectrum of AAO in patients with P/LP variants of each cognitive impairment disease-associated gene (only genes carried by two or more patients were included), in patients with and without P/LP variants of known cognitive impairment disease-associated genes. e Spectrum of AAO in FAD and SAD patients. f Spectrum of AAO in patients with and without APOE4. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns no significance. AAO age at onset, AD Alzheimer’s disease, FTD frontotemporal dementia, P/LP pathogenic or likely pathogenic, FAD familial Alzheimer’s disease, SAD sporadic Alzheimer’s disease.