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. 2021 Aug 13;11:16487. doi: 10.1038/s41598-021-95823-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of the expression of interferon regulatory factor 7 (IRF7) in corneal endothelial cells after herpes simplex virus 1 (HSV-1) infection. (a) The induction of the mRNA of IRF in human corneal endothelial (HCEn) cells after HSV-1 infection at multiplicity of infection (MOI) 1. IRF7 was induced 6 h post infection (PI), and a significant induction of IRF7 was maintained for 24 h PI. N = 4, ANOVA and Tukey test. (b) Network analysis of corneal endothelial cells after HSV-1 infection. IRF7 is centrally located in the highly significant primary network (P = 10^–36). Ingenuity pathway analysis 2020 (QIAGEN Inc. accessed on July 2020, https://digitalinsights.qiagen.com/products-overview/discovery-insights-portfolio/analysis-and-visualization/qiagen-ipa/) was used to generate the network map.