Table 1.
Significantly Altered Metabolites by Untargeted Metabolomics Under Cationic Mode
| Metabolite | VIP | Fold Change | P Value | m/z | rt(s) |
|---|---|---|---|---|---|
| Betaine | 8.953066 | 2.349001 | 0.000000 | 118.08524 | 510.7 |
| 4-Guanidinobutyric acid | 3.265833 | 4.179172 | 0.000000 | 146.09125 | 673.567 |
| Dimethylglycine | 1.918242 | 2.884359 | 0.000000 | 104.06937 | 564.983 |
| 1-Stearoyl-sn-glycerol 3-phosphocholine | 8.949199 | 2.402410 | 0.000000 | 524.36977 | 336.257 |
| 3-Aminobutanoic acid | 1.372053 | 6.369030 | 0.000001 | 104.0694 | 628.794 |
| Cellobiose | 1.204995 | 2.788409 | 0.000001 | 360.14902 | 749.718 |
| Xanthine | 2.173596 | 2.300530 | 0.000002 | 153.03982 | 395.371 |
| (3-Carboxypropyl)trimethylammonium cation | 5.708917 | 1.786359 | 0.000002 | 146.1169 | 714.139 |
| Methyl acetoacetate | 1.046955 | 2.504663 | 0.000003 | 116.04417 | 339.3485 |
| L-Carnitine | 1.525093 | 2.366309 | 0.000003 | 162.11155 | 719.441 |
| 1-O-(cis-9-Octadecenyl)-2-O-acetyl-sn-glycero-3-phosphocholine | 1.133253 | 2.173267 | 0.000004 | 550.38401 | 331.269 |
| 1-Methylnicotinamide | 1.503464 | 2.485537 | 0.000004 | 137.06985 | 548.3675 |
| Uracil | 4.943300 | 4.237295 | 0.000007 | 113.03348 | 144.069 |
| Allantoin | 1.915934 | 3.575247 | 0.000014 | 159.04983 | 339.119 |
| L-Citrulline | 1.484860 | 1.858884 | 0.000014 | 176.10198 | 741.18 |
| D-Pipecolinic acid | 1.104317 | 2.719950 | 0.000018 | 130.08489 | 579.57 |
| 1-Palmitoyl-sn-glycero-3-phosphocholine | 11.308273 | 1.546523 | 0.000026 | 496.33912 | 361.336 |
| 1-Oleoyl-sn-glycero-3-phosphocholine | 5.651979 | 1.698235 | 0.000032 | 522.35428 | 356.527 |
| 1-Stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 3.256977 | 2.130064 | 0.000037 | 482.32233 | 366.758 |
| Myo-Inositol | 2.534302 | 0.489591 | 0.000042 | 198.09639 | 747.817 |
| 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 2.231755 | 1.753614 | 0.000047 | 454.29152 | 373.4 |
| 2-Methylbutyroylcarnitine | 7.609122 | 3.217040 | 0.000048 | 246.16946 | 445.04 |
| Acetylcarnitine | 2.327520 | 2.344172 | 0.000074 | 204.12234 | 610.7025 |
| N-Acetyl-L-aspartic acid | 1.789313 | 0.600537 | 0.000126 | 176.05439 | 763.209 |
| L-Alanine | 1.651170 | 0.790843 | 0.000166 | 90.05378 | 656.4865 |
| Pantothenate | 1.539991 | 1.835488 | 0.000169 | 220.11705 | 518.703 |
| Gly-Glu | 1.744664 | 1.625211 | 0.000218 | 205.08169 | 811.507 |
| Anthranilic acid (Vitamin L1) | 4.130355 | 4.135162 | 0.000413 | 138.05411 | 535.905 |
| Caffeine | 1.487641 | 0.744461 | 0.000413 | 195.08664 | 81.9335 |
| D-Proline | 1.333765 | 1.502402 | 0.000504 | 116.06943 | 582.18 |
| Sn-Glycerol 3-phosphoethanolamine | 1.148223 | 0.409955 | 0.000534 | 216.0624 | 751.06 |
| Retinene | 2.280138 | 0.679650 | 0.000890 | 285.22027 | 63.458 |
| L-Palmitoylcarnitine | 3.637117 | 3.613271 | 0.000897 | 400.34122 | 321.835 |
| Gamma-L-Glutamyl-L-glutamic acid | 3.204750 | 0.420936 | 0.001050 | 277.10234 | 893.407 |
| 1-Methylhistamine | 1.212805 | 1.728684 | 0.001411 | 126.10137 | 628.794 |
| Cyclohexylamine | 4.490465 | 1.425476 | 0.001995 | 160.13257 | 729.001 |
| Acetylcholine | 1.161993 | 0.696391 | 0.002713 | 146.11621 | 349.639 |
| Creatine | 1.615463 | 0.551593 | 0.003827 | 132.07554 | 722.129 |
| Adenosine | 2.064261 | 0.550940 | 0.004720 | 285.12732 | 656.185 |
| L-Pyroglutamic acid | 2.245481 | 0.619670 | 0.004817 | 276.11817 | 830.854 |
| Taurine | 1.533283 | 1.596386 | 0.005044 | 126.02064 | 329.37 |
| L-Leucine | 1.185952 | 1.320973 | 0.008439 | 132.10098 | 490.0545 |
| 1-Myristoyl-sn-glycero-3-phosphocholine | 1.994833 | 1.515963 | 0.009542 | 468.30755 | 368.592 |
| Glycerophosphocholine | 3.384507 | 0.482741 | 0.010195 | 258.10931 | 735.46 |
| 4-Aminobutyric acid | 3.116019 | 0.731372 | 0.010626 | 104.0696 | 702.929 |
| 4-Hydroxybutanoic acid lactone | 2.382212 | 0.724217 | 0.012970 | 87.04301 | 703.082 |
| L-Aspartate | 2.339714 | 0.700536 | 0.018222 | 134.04385 | 773.456 |
| 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC) | 4.606284 | 3.106356 | 0.024919 | 788.6144 | 1172.295 |
| Adenine | 1.287452 | 0.601949 | 0.029236 | 136.06055 | 293.579 |
| Allopurinol riboside | 4.297267 | 0.778203 | 0.037926 | 537.16755 | 404.1 |
| Lathosterol | 1.314725 | 3.275910 | 0.040036 | 369.35081 | 1165.38 |
| Thioetheramide-PC | 3.237043 | 1.266703 | 0.041169 | 758.56859 | 269.8885 |
| 1,2-Dioleoyl-sn-glycero-3-phosphatidylcholine | 3.159002 | 1.298343 | 0.055688 | 786.59934 | 266.664 |
| 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine | 1.172687 | 2.401201 | 0.056496 | 718.53496 | 1167.655 |
| PC(16:0/16:0) | 8.734111 | 2.382445 | 0.068061 | 734.56849 | 1168.51 |
| 1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine | 1.469349 | 2.011624 | 0.073899 | 746.56768 | 1172.36 |
| Creatinine | 1.364756 | 0.769696 | 0.081739 | 114.06474 | 312.308 |
| Inosine | 3.961990 | 0.816050 | 0.088064 | 269.08745 | 404.105 |