Table 2.
Significantly Altered Metabolites by Untargeted Metabolomics Under Anionic Mode
| Metabolite | VIP | Fold Change | P Value | m/z | rt(s) |
|---|---|---|---|---|---|
| Acetylcarnitine | 1.454661 | 2.434390 | 0.000000 | 262.1294 | 571.791 |
| L-Glutamate | 1.256184 | 3.821374 | 0.000000 | 146.04638 | 744.064 |
| 2E-Eicosenoic acid | 1.763247 | 1.452142 | 0.000000 | 309.27977 | 77.679 |
| 4-Guanidinobutyric acid | 1.332435 | 6.088734 | 0.000000 | 144.07809 | 669.805 |
| Xanthine | 6.642292 | 2.346172 | 0.000001 | 151.0265 | 383.609 |
| 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 2.764355 | 1.859510 | 0.000004 | 452.27722 | 373.564 |
| (+-)12-HETE | 5.306001 | 2.499252 | 0.000004 | 319.22784 | 84.953 |
| Myristoleic acid | 3.118652 | 2.280041 | 0.000007 | 225.18586 | 83.528 |
| D-(+)-Melibiose | 1.337255 | 2.247703 | 0.000011 | 341.10845 | 746.496 |
| Pantothenate | 3.027996 | 2.547344 | 0.000013 | 218.10383 | 510.606 |
| L-Carnitine | 3.258514 | 2.588557 | 0.000020 | 220.11952 | 664.11 |
| Myo-Inositol | 7.340530 | 0.476325 | 0.000044 | 179.05653 | 743.717 |
| Glycocholic acid | 1.003178 | 1.916077 | 0.000046 | 464.31154 | 349.503 |
| Uracil | 6.734364 | 3.519054 | 0.000069 | 111.0201 | 168.358 |
| D-Mannose | 6.975081 | 0.425147 | 0.000092 | 239.07745 | 743.717 |
| Glycine | 3.759812 | 2.027606 | 0.000095 | 74.02505 | 680.283 |
| Maltotriose | 1.052258 | 2.421338 | 0.000131 | 563.18163 | 865.745 |
| Oleic acid | 6.806489 | 1.759083 | 0.000132 | 281.24894 | 110.021 |
| Allantoin | 3.540601 | 2.890388 | 0.000137 | 157.03705 | 337.978 |
| L-Citrulline | 1.403042 | 1.709572 | 0.000253 | 174.08906 | 739.842 |
| D-Proline | 1.742049 | 1.569806 | 0.000385 | 114.05627 | 576.359 |
| L-Valine | 1.587966 | 1.497543 | 0.000450 | 116.07191 | 560.089 |
| Sn-Glycerol 3-phosphoethanolamine | 1.991441 | 0.382196 | 0.000586 | 214.04908 | 749.794 |
| N-Acetyl-L-aspartic acid | 7.576935 | 0.632832 | 0.000640 | 174.04114 | 764.751 |
| DL-2-Aminoadipic acid | 1.089888 | 2.125641 | 0.000886 | 160.06185 | 787.333 |
| Palmitic acid | 8.007681 | 1.124176 | 0.001089 | 255.2332 | 82.059 |
| Gamma-L-Glutamyl-L-glutamic acid | 2.601294 | 0.416845 | 0.001448 | 275.08845 | 897.509 |
| Adrenic Acid | 3.755722 | 1.267188 | 0.002212 | 331.26359 | 76.565 |
| D-Galactarate | 1.787986 | 0.551609 | 0.002474 | 191.01936 | 286.1585 |
| Pseudouridine | 1.141947 | 1.806677 | 0.003126 | 243.06197 | 447.9605 |
| Creatine | 3.540442 | 0.722911 | 0.006794 | 130.06261 | 652.947 |
| Cis-9-Palmitoleic acid | 4.058978 | 2.240018 | 0.008495 | 253.21774 | 110.293 |
| L-Alanine | 3.306320 | 0.783691 | 0.014585 | 88.04076 | 652.824 |
| Pyridoxal (Vitamin B6) | 1.311114 | 1.586000 | 0.014743 | 166.05095 | 162.597 |
| Norethindrone Acetate | 3.483931 | 1.379377 | 0.020288 | 339.19959 | 83.273 |
| Stearic acid | 5.603181 | 2.729253 | 0.021242 | 283.26433 | 244.98 |
| L-Malic acid | 4.072239 | 0.743349 | 0.022810 | 133.01471 | 783.252 |
| Adenine | 1.626748 | 0.631079 | 0.024188 | 134.04716 | 281.5275 |
| Linoleic acid | 2.920425 | 1.513296 | 0.025747 | 279.23299 | 109.611 |
| Citrate | 1.156295 | 2.222213 | 0.027596 | 191.02026 | 979.294 |
| Glycerol 3-phosphate | 1.650010 | 0.667400 | 0.030425 | 171.00679 | 837.313 |
| Myristic acid | 4.788453 | 1.245557 | 0.031348 | 227.20215 | 83.989 |
| Inosine | 10.909695 | 0.797612 | 0.034407 | 267.0736 | 396.051 |
| Hypoxanthine | 4.863956 | 1.231164 | 0.036415 | 135.03152 | 293.914 |
| L-Aspartate | 4.098384 | 0.741791 | 0.047288 | 132.03067 | 774.182 |
| D(-)-beta-hydroxy butyric acid | 1.166855 | 1.406794 | 0.056202 | 103.04025 | 345.8365 |
| L-Norleucine | 2.819077 | 1.274431 | 0.060061 | 130.08762 | 487.643 |
| Dihomo-gamma-Linolenic Acid | 1.376884 | 1.427861 | 0.066364 | 305.24759 | 119.618 |
| (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1 6,19-Docosahexaenoic acid | 5.555343 | 2.162096 | 0.068306 | 327.23252 | 138.446 |