Figure 7.

Model depicting HMS-mediated stabilization of HOXC10 by recruitment of RNA stabilizing protein, HuR.A, correlation analysis between the expression of HMS and HOXC10 in the LUAD samples of the TCGA database. Spearman rank correlation was used to assess relationships between lncRNA and mRNA expression, which showed a positive correlation coefficient, “r” >0.5 with a p-value <0.001 (Student’s t test). B, The HOXC10 gene is located 135 kb upstream of the HMS gene locus and both are expressed in the same direction from the “+” strand of chromosome 12, as depicted by arrows. At low levels of HMS, the RNA stabilizing protein HuR is not recruited to the 3′ untranslated region of HOXC10 mRNA resulting in its destabilization (depicted on the right side of the illustration). In the presence of HMS, HuR is recruited to the HOXC10 3′UTR stabilizing its mRNA and thus maintaining the oncogenic properties of cancer cells (left side of the illustration). The Genotype-Tissue Expression (GTEx) data reveals that in most of the tissues a high HOXC10 expression is accompanied by high levels of HMS expression.