FIGURE 3.

Clinical context‐dependent analysis of protein landscape of EV and LPP extracts. (a) Correlation matrix of LFQ protein intensities of EV and LPP extracts obtained by fractionation of blood plasma from breast cancer patients (n = 6), ovarian cancer patients (n = 4; 5 time points) and HIV patients (n = 6; 2 time points). (b) Summed peptide count of EV‐associated proteins (ANXA2, CD9, EZR, HSPA7, MSN and SDCBP) in EV extracts across clinical conditions. (c) Schematic representation of an EV showing the functional annotation and localization of enriched proteins in EV extracts across clinical conditions. (d) Biological process enrichment and (e) functional pathway analysis of proteins enriched in EV extracts from HIV patients