Table 2.
Left Ventricular Structure, Function, and Myocardial Tissue Characterization
| Preterm-Born Adults (n = 47) | Term-Born Adults (n = 54) | P Value | |
|---|---|---|---|
| CMR structural parameters | |||
| End-diastolic volume/BSA, mL/m2 | 72.02 ± 10.81 | 88.21 ± 11.49 | <0.001 |
| End-systolic volume/BSA, mL/m2 | 27.81 ± 8.90 | 33.40 ± 6.61 | <0.001 |
| Myocardium mass, g | 104.77 ± 19.31 | 98.06 ± 18.32 | <0.001 |
| Myocardium mass/BSA, g/m2 | 60.01 ± 7.25 | 53.05 ± 6.80 | <0.001 |
| Mass/end-diastolic volume, g/mL | 0.87 ± 0.09 | 0.60 ± 0.10 | <0.001 |
| Average wall thickness, mm | 8.33 ± 0.84 | 5.80 ± 0.96 | <0.001 |
| CMR functional parameters | |||
| Ejection fraction, % | 61.33 ± 4.44 | 62.28 ± 4.52 | 0.325 |
| Stroke volume/BSA, mL/m2 | 44.20 ± 7.50 | 54.81 ± 7.32 | <0.001 |
| Longitudinal systolic strain, % | −15.35 ± 1.58 | −18.75 ± 2.27 | <0.001 |
| Longitudinal systolic strain rate, s−1 | −0.93 ± 0.20 | −1.08 ± 0.24 | 0.002 |
| Circumferential systolic strain, % | −18.31 ± 2.09 | −18.48 ± 2.24 | 0.893 |
| Circumferential systolic strain rate, s−1 | −1.03 ± 0.14 | −1.03 ± 0.21 | 0.953 |
| Longitudinal diastolic strain rate, s−1 | 0.99 ± 0.23 | 1.14 ± 0.26 | 0.009 |
| Circumferential diastolic strain rate, s−1 | 1.54 ± 0.38 | 1.65 ± 0.34 | 0.203 |
| Echocardiographic functional parameters | |||
| Longitudinal systolic strain, % | −19.32 ± 2.72 | −20.15 ± 3.16 | 0.019 |
| Longitudinal systolic strain rate, s−1 | −1.04 ± 0.18 | −1.18 ± 0.31 | 0.063 |
| Circumferential systolic strain, % | −25.66 ± 4.01 | −26.70 ± 3.22 | 0.321 |
| Circumferential systolic strain rate, s−1 | −1.67 ± 0.30 | −1.57 ± 0.28 | 0.156 |
| Longitudinal diastolic strain rate, s−1 | 1.49 ± 0.39 | 1.82 ± 0.61 | 0.008 |
| Circumferential diastolic strain rate, s−1 | 2.20 ± 0.70 | 2.26 ± 0.58 | 0.706 |
| +E/A ratio | 1.52 ± 0.38 | 1.75 ± 0.42 | 0.013 |
| +E/e’ ratio | 4.90 ± 1.13 | 4.96 ± 1.04 | 0.768 |
| CMR myocardial tissue characterization | |||
| ECV, % | 27.81 ± 1.69 | 25.48 ± 1.41 | <0.001 |
| Native T1 myocardium, ms | 1173.81 ± 29.29 | 1169.24 ± 41.13 | 0.908 |
| LGE mass, g | 0.45 (0.049-3.04) | 0.43 (0.027-3.51) | 0.845 |
| Relative LGE mass, % | 0.42 (0.034-3.81) | 0.44 (0.035-3.85) | 0.557 |
Values are mean ± SD or median (range). P values are adjusted for sex. P values in bold indicate statistical significance (P < 0.05). Average wall thickness and circumferential strain measures are from the midventricular short-axis slice.
BSA = body surface area; CMR = cardiovascular magnetic resonance; ECV = extracellular volume; LGE = late gadolinium enhancement.