Table 1.

This table summarizes the studies that have examined the role of ovarian hormones in preclinical models of cocaine and opioid use disorder. The rows for each drug reflect changes to behavioral phenotypes following OVX and OVX + estradiol replacement. The line symbolizes that no studies have examined this directly.

OVX
	CPP	Self-administration	Seeking	PR Responding
Cocaine	↓	↓	↓	-
Opioids	↓, ↑	No effect	No effect	No effect
OVX + estradiol replacement
	CPP	Self-administration	Seeking	PR Responding
Cocaine	↑	↑	↑	↑
Opioids	↑, No effect	↑, No effect	↓, No effect	No effect

This table summarizes the studies that have examined the role of ovarian hormones in preclinical models of cocaine and opioid use disorder. The rows for each drug reflect changes to behavioral phenotypes following OVX and OVX + estradiol replacement. The line symbolizesthat no studies have examined this directly