Table 3.
Genes with good or highly suggestive evidence of specific relevance to obesity, diabetes and metabolic syndrome
| Gene | Disease Association or trait reported in humans | Putative mechanism |
|---|---|---|
| C-Type Lectin Domain Containing 10 A (CLEC10A) | Obesity, T2D | Adaptive and immune responses |
| Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) | T2D | Regulator of beta cell function and of immune function |
| Neuronal Growth Regulator 1 (NEGR1) | BMI, wait circumference, T2D | Cell adhesion |
| NAD(P)H Quinone Dehydrogenase 1 (NQO1) | Obesity, T2D. liver dysfunction | Anti-oxidant defences |
| Inhibin Subunit Beta E (INHBE ) | Metabolic Syndrome, coronary heart disease | Cell proliferation, apoptosis, immune responses and hepatokine and hormone secretion |
| Glutamate receptor interacting protein 1 (GRIP1) | Metabolic syndrome (hepatic steatosis, hyperglycaemia and increased insulin resistance) | Macrophage and neuronal function and increased inflammation |
| Clusterin (CLU) | Glucose intolerance | Increased insulin resistance |
| Growth Factor Binding Protein 3 (IGFBP3) | Obesity, T2D, cerebrovascular disease | IGF binding protein affects vitamin D metabolism |
| Potassium Voltage-Gated Channel Subfamily Q Member 5 (KCNQ5) | Body mass index | Potassium channel |
| Cytotoxic And Regulatory T-Cell Molecule (CRTAM) | Body mass index and systolic hypertension | Innate immune system and determinant of insulin secretion |
| Spectrin (SPTA1) | HbA1c and T2D | Stability and structure of the cell membrane contributing to cell adhesion, cell spreading, and the cell cycle |
Legend: T2D type 2 diabetes, HbA1c glycosylated haemoglobin