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. 2021 Aug 6;118(32):e2022136118. doi: 10.1073/pnas.2022136118

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Fig. 6. — DAVID analysis of transcripts down- and up-regulated by VapC4. (A) VapC4 engages multiple mechanisms for growth control. DAVID Functional Analysis Tool terms (38, 39) associated with genes that were significantly (twofold) down-regulated after 24 h of VapC4 induction by total RNA-seq analysis. (B) VapC4 mimics Cys starvation to activate the oxidative and Cu stress responses. DAVID terms associated with genes that were significantly (twofold) up-regulated after 24 h of VapC4 induction by RNA-seq analysis. The dotted lines in both A and B represent a twofold enrichment between the proportion of the term in the observed genes compared to the expected proportion of the term when considering all genes in the genome. The area of each circle in both A and B is proportional to the number of observed genes in the corresponding category.