TABLE 1.
Planning information for the ipsilateral lung of each analyzed patient
| Patient | AVG‐AVG DIR TRE [mm] | Patient Characteristics | Dose Metrics | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Diaph motion [mm] | GTV motion [mm] | GTV to Diaph [mm] | GTV vol [cm3] | PTV% | GTV DHI | DHI of normal lung | |ΔMLD| [cGy] | |ΔV20| | ≥2 Gy% | ||
| 1 | 2.0 | 16.0 | 4.4 | 80 | 9 | 13.4 | 3.5 | 0.9 | 7 | 0.1 | 2.1 |
| 2 | 2.3 | 7.6 | 1.5 | 79 | 32 | 11.0 | 4.2 | 0.9 | 7 | 0.0 | 9.6 |
| 3 | 1.8 | 5.1 | 1.7 | 73 | 25 | 8.4 | 2.4 | 0.9 | 20 | 0.3 | 0.0 |
| 4 | 2.2 | 19.5 | 4.0 | 124 | 5 | 3.1 | 2.6 | 0.5 | 7 | 0.4 | 4.8 |
| 5 | 2.6 | 10.4 | 6.2 | 20 | 19 | 13.8 | 2.9 | 0.8 | 55 | 0.8 | 16.5 |
| 6 | 2.4 | 10.2 | 0.8 | 56 | 90 | 18.1 | 1.8 | 1.0 | 15 | 0.1 | 0.4 |
| 7 | 2.7 | 5.5 | 0.6 | 85 | 9 | 10.4 | 2.2 | 0.9 | 37 | 0.6 | 6.3 |
| 8 | 5.7 | 4.5 | 0.9 | 76 | 21 | 5.5 | 3.5 | 0.5 | 5 | 0.1 | 2.1 |
| 9 | 1.7 | 14.7 | 0.6 | 35 | 29 | 12.4 | 2.4 | 1.0 | 20 | 0.3 | 3.2 |
| 10 | 3.1 | 27.3 | 3.7 | 27 | 180 | 8.6 | 4.6 | 0.9 | 80 | 2.0 | 16.6 |
| 11 | 2.1 | 8.3 | 1.4 | 19 | 12 | 12.1 | 2.5 | 0.9 | 11 | 0.1 | 4.3 |
| 12 | 3.1 | 5.5 | 1.9 | 32 | 193 | 24.1 | 4.0 | 1.0 | 16 | 0.1 | 6.0 |
| 13 | 1.9 | 26.5 | 0.9 | 81 | 8 | 7.1 | 2.6 | 0.7 | 1 | 0.0 | 2.1 |
| 14 | 4.8 | 5.0 | 0.5 | 12 | 18 | 7.3 | 2.6 | 0.8 | 84 | 1.6 | 15.5 |
| 15 | 2.2 | 6.2 | 4.0 | 90 | 1 | 8.1 | 2.7 | 0.8 | 28 | 0.9 | 17.8 |
| 16 | 4.7 | 9.3 | 0.4 | 93 | 363 | 13.4 | 3.0 | 1.0 | 18 | 0.2 | 12.2 |
| 17 | 2.7 | 10.4 | 1.7 | 80 | 192 | 23.4 | 4.1 | 0.9 | 12 | 0.1 | 10.2 |
| 18 | 3.8 | 14 | 3.6 | 112 | 235 | 12.6 | 4.2 | 1.0 | 32 | 0.1 | 11.8 |
| 19 | 2.4 | 1.4 | 2.8 | 25 | 53 | 16.8 | 1.7 | 0.8 | 39 | 0.5 | 5.3 |
| 20 | 5.0 | 9.6 | 3.0 | 75 | 28 | 8.1 | 4.5 | 0.8 | 2 | 0.2 | 11.7 |
| 21 | 2.3 | 1.0 | 0.6 | 90 | 21 | 7.7 | 2.5 | 0.8 | 1 | 0.0 | 0.9 |
| 22 | 4.3 | 3.6 | 1.8 | 94 | 35 | 12.3 | 2.2 | 0.9 | 21 | 0.5 | 10.7 |
| 23 | 2.4 | 10.6 | 1.0 | 101 | 9 | 8.6 | 6.3 | 1.0 | 38 | 0.6 | 8.8 |
| 24 | 5.4 | 7.8 | 4.7 | 51 | 23 | 4.7 | 3.3 | 0.5 | 21 | 0.2 | 21.6 |
| 25 | 2.3 | 17.7 | 2.2 | 72 | 41 | 13.9 | 2.9 | 0.9 | 55 | 0.8 | 7.4 |
| 26 | 3.3 | 28.3 | 7.7 | 90 | 33 | 5.3 | 2.4 | 0.6 | 48 | 1.0 | 8.2 |
| 27 | 1.9 | 14.2 | 8.6 | 55 | 19 | 11.2 | 3.6 | 0.9 | 5 | 0.0 | 10.9 |
| 28 | 4.6 | 15.1 | 2.9 | 81 | 53 | 18.5 | 3.3 | 0.9 | 58 | 0.7 | 10.7 |
Patient Characteristics columns: Diaph motion: the largest distance between two voxels on the diaphragm between end‐exhalation phase and end‐inhalation phase along the superior‐inferior direction. GTV motion: the distance between the center of gravity of the GTVs in end‐exhalation phase and end‐inhalation phase along the superior‐inferior direction. GTV to Diaph: the distance between the center of gravity of the GTV to the diaphragm along the superior‐inferior direction. GTV vol: volume of GTV inside normal lung (lung volume excluding GTV). PTV%: percent PTV volume in normal lung.
Dose Metrics columns: |ΔMLD|: absolute difference in MLD between the planned dose deformed with AVG‐AVG DIR versus with T5‐T5 DIR. |ΔV20|: absolute difference in V20 between the planned dose deformed with AVG‐AVG DIR versus with T5‐T5 DIR. ≥2 Gy%: Portion of T5 landmarks with ≥2 Gy absolute dose difference between doses mapped with AVG‐AVG DIR versus T5‐T5 DIR.
Abbreviations: AVG, average‐intensity image; Diaph, diaphragm; DHI, dose homogeneity index; DIR, deformable image registration; GTV, gross tumor volume; MLD, mean lung dose; PTV, planning target volume; TRE, target registration error; V20, volume of lung receiving at least 20 Gy.