Fig. 2.

Pathway searching pipeline. Step1 selects seed ROIs with high tau-PET signals among the subjects (i.e., tau+ prevalence > 80%). Step2 identifies all possible connections from the seeds (gray sticks). For each connection, two linear regressions were performed as shown in Step3. If both tests revealed significant results, the connection was considered an association pathway and was highlighted in Step4. Steps 2–4 were reiterated until no further pathways were detected.