Fig. 4.
An illustration of the iterative approach in DDIS. The searching started from initial 14 seed ROIs (red circles in Iteration 1) clustered mainly in the medial temporal lobe. All possible connections from the seed ROIs were initially colored gray (top row). Two linear regressions were performed on each connection (middle row) to determine TAUup-MD-TAUdown associations. The significant pathways were assigned colors (bottom row). The colored ROIs (TAUdown) served as seed ROIs (TAUup) in the next iteration. Note that the purpose of this figure is to illustrate the behind-the-scene process of the iterative approach. The identified/survived pathways and nodes were listed in Fig. 5 with full names and matched colors. The full form of the abbreviations is also listed in Fig. 3 left two columns.