Fig. 5.

Summary of identified pathways for the tau-PET signal and MD association. Each colored pathway contains a dual association between tau-PET signal at both ends and MD in the tract. Involved GM ROIs are listed below with matching colors representing the stages/iterations in DDIS in Fig. 4. Out of 22 identified pathways, 14 were found in both hemispheres, indicated by a star (*) on the connections in the bottom figure. The red circles with a cross inside the circle, ⊗, denote those initial seed ROIs known to have off-target tau bindings. These ROIs were located in the basal ganglia, including the pallidum, caudate, putamen, and thalamus. STS: superior temporal sulcus. L: left hemisphere. R: right hemisphere.