Fig. 8.
The tau-WM association patterns between the full sample and amyloid positive participants. Top row left: the association pattern derived from all the participants. Top middle: the scatter plot for the tau-PET signal in the seed GM (TAUup) vs. mean diffusivity (MD) along the connecting WM tract in one of the early pathways (i.e., the inferior temporal to the inferior parietal ROI). Top right: in the same pathway, the scatter plot for MD along the WM tract vs. the tau-PET signal in the destination GM ROI (TAUdown). The black regression line represents all the participants including cognitively normal (CN, blue dots), individuals with subjective cognitive decline (SCD, blue dots), and with mild cognitive impairment (MCI, red dots). The r2 values are the adjusted r2 (coefficient of determination) describing additional variance explained by the independent variable in addition to the covariates (i.e., age and sex). P denotes the P value of the linear regression. Bottom row left: the association pattern derived from the amyloid positive participants (n = 17, Table 1). Bottom middle: the scatter plot for TAUup vs. MD in the same pathway (inferior temporal to the inferior parietal) in the amyloid positive participants (purple dots). Bottom right: the scatter plot for MD vs. TAUdown. The purple regression line represents the amyloid positive participants only.