Table 2.
A list of highly significant pathways (i.e., valid connection) with P values less than 0.01.
| Hemisphere | TAUup ROI | TAUdown ROI | p 1 | p 2 |
|---|---|---|---|---|
| L | middle temporal | inferior parietal | 0.00014 | 0.00007 |
| L | middle temporal | STS | 0.00012 | 0.00006 |
| L | inferior temporal | lateral occipital | 0.00025 | 0.00005 |
| L | inferior temporal | inferior parietal | 0.00003 | 0.00006 |
| L | fusiform | lingual | 0.00019 | 0.00019 |
| L | fusiform | lateral occipital | 0.00160 | 0.00025 |
| L | lateral occipital | superior parietal | 0.00016 | 0.00150 |
| L | lateral occipital | pericalcarine | 0.00170 | 0.00750 |
| L | lateral occipital | cuneus | 0.00076 | 0.00048 |
| L | inferior parietal | supramarginal | 0.00450 | 0.00370 |
| L | inferior parietal | superior parietal | 0.00240 | 0.00730 |
| L | STS | superior temporal | 0.00490 | 0.00270 |
| L | precuneus | isthmus cingulate | 0.00120 | 0.00091 |
| L | postcentral | paracentral | 0.00580 | 0.00720 |
| R | middle temporal | inferior parietal | 0.00036 | 0.00090 |
| R | middle temporal | STS | 0.00230 | 0.00150 |
| R | inferior temporal | lateral occipital | 0.00002 | 0.00030 |
| R | inferior temporal | inferior parietal | 0.00038 | 0.00100 |
| R | fusiform | lingual | 0.00009 | 0.00034 |
| R | fusiform | lateral occipital | 0.00014 | 0.00040 |
| R | lateral occipital | superior parietal | 0.00170 | 0.00610 |
| R | lateral occipital | cuneus | 0.00024 | 0.00002 |
| R | superior parietal | precuneus | 0.00460 | 0.00930 |
| R | superior parietal | postcentral | 0.00390 | 0.00044 |
| R | precuneus | isthmus cingulate | 0.00043 | 0.00040 |
P1 denotes the P value for the association between TAUup and DiffWM (i.e., tau in the seed ROI and the diffusion metric along its connecting WM tract) in that particular connection. In the same connection, P2 denotes the P value for the association between DiffWM and TAUdown (i.e., the diffusion metric along the WM tract and tau in the tract’s destination GM ROI). P values less than 0.001 are further highlighted in blue. L denotes the left hemisphere and R denotes the right hemisphere.
STS: banks of the superior temporal sulcus