Table 3.
Associations Between PeV-A Ct Levels and RTI, Comparing Children with RTI (n = 3689) and Asymptomatic Children in a Comparison Group (n = 444) in Logistic Regression Models
| Model Aa,c | Model Bb,c | |||
|---|---|---|---|---|
| OR | (95% CI) | OR | (95% CI) | |
| PeV-A | ||||
| Ct <28 | 1.24 | (0.50-3.11) | 1.13 | (0.42-3.04) |
| Ct 28-35 | 0.95 | (0.55-1.63) | 1.26 | (0.60-2.64) |
| Ct >35 | 0.70 | (0.41-1.20) | 0.71 | (0.22-2.26) |
| Codetected viruses | 7.53 | (5.32-10.65) | 7.97 | (5.51-11.52) |
| Age, months | ||||
| < 6 | 4.33 | (2.62-7.16) | 4.44 | (2.68-7.37) |
| 6-11 | 1.65 | (1.06-2.56) | 1.71 | (1.08-2.69) |
| 12-23 (reference) | .. | .. | .. | .. |
| 24-59 | 0.31 | (0.23-0.41) | 0.33 | (0.25-0.44) |
| ≥60 | 0.19 | (0.13-0.27) | 0.20 | (0.14-0.29) |
| Sex, male | 0.32 | (0.25-0.42) | 0.34 | (0.25-0.44) |
| Chronic diseased | 6.92 | (4.58-10.46) | 6.83 | (4.49-10.40) |
| Premature birth | 1.53 | (1.03-2.28) | 1.49 | (0.98-2.25) |
Abbreviations: CI, confidence interval; OR, odds ratio; Ct, cycle threshold; PeV-A, Parechovirus A; RTI, respiratory tract infections.
aModel A includes PeV-A detections in children with RTI (n = 323) and in the comparison group (n = 45).
bModel B includes PeV-A genotypes 1 and 6 detections in children with RTI (n = 167) and in the comparison group (n = 23).
cAdjusting for codetected viruses (respiratory syncytial virus, influenza virus A and B, human metapneumovirus, and/or parainfluenza virus type 1-3) and age group, sex, chronic disease, and premature birth.
dChronic disease includes asthma, cerebral palsy, epilepsy, immunodeficiency, and heart disease.