Table 2.
The Mean Non-Compartmental Pharmacokinetic Parameters of 125I-INS061 After a Single Intravenous or Subcutaneous Injection in Rats by RA Method (n=6)
| Parameter | Unit | Subcutaneous Injection | Intravenous Injection | ||
|---|---|---|---|---|---|
| 0.75 IU/kg | 1.5 IU/kg | 3.0 IU/kg | 1.5 IU/kg | ||
| t1/2 | h | 6.06 ± 0.902 | 6.53 ± 1.64 | 6.38 ± 1.85 | 2.54±0.422 |
| Tmax | h | 3.50 ± 0.548 | 3.00 ± 0.632 | 2.33 ± 0.816 | 0.083 |
| Cmax | ng/mL | 30.09 ± 5.47 | 67.44 ± 9.13 | 137.12 ± 18.50 | 390.78±81.12 |
| AUC0-t | ng/mL/h | 237.43 ± 32.93 | 459.72 ± 65.73 | 880.08 ± 95.30 | 649.84±80.65 |
| AUC0-∞ | ng/mL/h | 251.48 ± 35.82 | 485.26 ± 67.23 | 917.66 ± 95.39 | 656.29±77.05 |
| MRT | h | 8.14 ± 0.706 | 7.39 ± 0.745 | 6.56 ± 0.869 | 2.88±0.556 |
| Vd (Vd/F) | L/kg | 0.277 ± 0.122 | 0.261 ± 0.066 | 0.267 ± 0.069 | 0.076±0.024 |
| Cl (Cl/F) | L/kg/h | 0.031 ± 0.012 | 0.028 ± 0.004 | 0.029 ± 0.003 | 0.021±0.003 |
| Fabs | % | - | 73.94 | - | - |