Table 3.

The Mean Non-Compartmental Pharmacokinetic Parameters of ¹²⁵I-INS061 After a Single Intravenous or Subcutaneous Injection in Rats by TCA-RA Method (n=6)

Parameter	Unit	Subcutaneous Injection			Intravenous Injection
		0.75 IU/kg	1.5 IU/kg	3.0 IU/kg	1.5 IU/kg
t1/2	h	5.61 ± 1.19	5.17 ± 1.05	4.81 ± 1.11	2.40 ± 0.61
Tmax	h	2.50 ± 0.548	2.33 ± 0.516	2.17 ± 0.753	0.083
Cmax	ng/mL	24.94 ± 6.06	54.61± 9.39	108.78 ± 20.36	339.73 ± 72.33
AUC0-t	ng/mL/h	146.72 ± 20.29	309.76 ± 50.49	617.74 ± 81.78	442.23±76.74
AUC0-∞	ng/mL/h	156.63 ± 22.51	323.31 ± 52.47	633.28 ± 82.87	446.75±77.10
MRT	h	7.64 ± 0.899	6.19 ± 0.181	5.6 ± 0.406	2.08±0.310
Vd (Vd/F)	L/kg	0.346 ± 0.070	0.308 ± 0.044	0.296 ± 0.075	0.103±0.020
Cl (Cl/F)	L/kg/h	0.043 ± 0.006	0.042 ± 0.006	0.043 ± 0.005	0.030±0.004
Fabs	%	-	70.04	-	-