Table 4.
Comparison of Main Pharmacokinetic Parameters Determined by RA, TCA-RA and HPLC-RA Methods After a Single Subcutaneous Injection of 125I-INS061 at a Dose of 1.5 IU/Kg in Rats (n=6)
| Parameter | Unit | HPLC-RA | TCA-RA | RA |
|---|---|---|---|---|
| t1/2 | h | 4.21 ± 1.69 | 5.17 ± 1.05 | 6.53 ± 1.64 |
| Tmax | h | 2.33 ± 0.516 | 2.33 ± 0.516 | 3.00 ± 0.632 |
| Cmax | ng/mL | 60.78 ± 7.50 | 54.61± 9.39 | 67.44 ± 9.13 |
| AUC0-t | ng/mL/h | 289.33 ± 34.39 | 309.76 ± 50.49 | 459.72 ± 65.73 |
| AUC0-∞ | ng/mL/h | 303.06 ± 33.08 | 323.31 ± 52.47 | 485.26 ± 67.23 |
| Cl (Cl/F) | L/kg/h | 0.044 ± 0.005 | 0.042 ± 0.006 | 0.028 ± 0.004 |