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. 2021 Aug 10;14:3555–3566. doi: 10.2147/DMSO.S323009

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© 2021 Xu et al.

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Plasma nesfatin-1 might be involved in the comorbidity of T2DM and cognitive dysfunction, and the mechanism underlying this involvement is related to the imbalance expression of CRP, IL-6, sTREM1, and sTREM2.

Notes: The nesfatin-1 in plasma was positively correlated with the plasma HbA1c levels and the CRP, IL-6, sTREM1, and sTREM2 levels in patients with T2DM. Moreover, T2DM patients with high nesfatin-1 levels showed higher scales of BRIEF-A. Furthermore, the plasma nesfatin-1 level may be considered as a biomarker to identify T2DM patients with high total scores of BRIEF-A. Collectively, these data suggest that plasma nesfatin-1 might be involved in the comorbidity of T2DM and cognitive dysfunction, and the mechanism underlying this involvement is related to the imbalance expression of CRP, IL-6, sTREM1, and sTREM2.