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. 2021 Aug 10;13:6291–6307. doi: 10.2147/CMAR.S321433

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© 2021 Huang et al.

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Key metabolites in methionine and glutamine metabolism. The metabolic reactions closely related to SAM and GSH production are shown. SAM is a universal methyl donor and primarily regulates methylation. GSH mainly modify glutathionylation through binding to the cysteine residues of proteins.

Abbreviations: GSH, glutathione; MAT, adenosyltransferase; MT, methyltransferases; SAM, s-adenosyl-methionine; SAH, s-adenosyl-homocysteine; HCY, homocysteine; GLS, glutaminases; GCL, glutamate cysteine ligase; GSS, GSH synthetase.