Table 2.

Improvement in “Best Corrected Visual Acuity” (BCVA) and Decrease of Central Macular Thickness (CMT) at Month 12

Improvement in BCVA (in Terms of Letter Gain) and Decrease in CMT (µm) from Baseline to Month 12	RBZ + Laser	BVZ + Laser	p-value
Mean change in BCVA in RBZ+Laser, (n = 77) and BVZ+Laser (n = 51) group	6.87±5.53	6.82 ± 5.76	0.858
Mean change in BCVA among moderate NPDR+Focal DME subjects (RBZ+Laser, n = 40; BVZ+Laser, n = 25)	11.30±3.603	11.96±3.020	0.540
Mean change in BCVA among severe NPDR+Diffused DME subjects (RBZ+Laser, n = 24; BVZ+Laser, n = 15)	3.125±2.232	3.200±2.455	0.801
Mean change in BCVA among PDR+Diffused DME subjects (RBZ+Laser, n = 24; BVZ+Laser, n = 15)	0.153±0.3755	0.090±0.301	0.999
Mean change in CMT (µm) in RBZ+Laser, (n = 77) and BVZ+Laser (n = 51) group	140.1±38.00	134.9±40.32	0.300
Mean change in CMT (µm) among moderate NPDR+Focal DME subjects (RBZ+Laser, n = 40; BVZ+Laser, n = 25)	171.9±3.770	170.6±3.830	0.192
Mean change in CMT (µm) among severe NPDR+Diffused DME subjects (RBZ+Laser, n = 24; BVZ+Laser, n = 15)	122.3±7.097	120.1±7.869	0.375
Mean change in CMT (µm) among severe PDR+Diffused DME subjects (RBZ+Laser, n = 24; BVZ+Laser, n = 15)	75.08±20.54	74.18±20.84	0.9168

Notes: Data were presented as mean ± SD. Normally distributed variables of two groups were compared by unpaired Student’s t-test. Not-normally distributed variables of the two groups were compared by the Mann–Whitney U-test. No significant differences were observed in the recovery of VA and decrement of CMT when compared RBZ+Laser group with BVZ+Laser groups. A value of p < 0.05 was considered statistically significant.

Abbreviations: BCVA, best-corrected visual acuity; CMT, central macular thickness.